A radio- and fluorescently labelled tracer for imaging and quantification of bacterial infection on orthopaedic prostheses
A helpful and promising tool to locate the parts to be treated with IPD’s induction technology AimsArthroplasty surgery of the knee and hip is performed in two to three million patients annually.Periprosthetic joint infections occur in 4% of these patients. Debridement, antibiotics,and implant retention (DAIR) surgery aimed at cleaning the infected prosthesis oftenfails, subsequently requiring […]
Effectiveness of mechanical cleaning,
antibiotics, and induction heating on
eradication of Staphylococcus aureus in
mature biofilms
Here we used a mature seven- day biofilm model of Staphylococcus aureus, exposed to anti-biotics up to an additional seven days, to establish the effectiveness of either mechanical cleaning or antibiotics or non- contact induction heating, and which combinations could eradicate S. aureus in mature biofilms.
Synergistic effects of Non Contact Induction Heating & Antibiotics on Staphylococcus aureus Biofilm
Staphylococcus aureus is a major cause of prosthetic joint infection (PJI) in which it forms adherent biofilms, thick aggregates of extracellular polymeric substances (EPS) produced by the bacteria. Biofilm associated infections are difficult to treat as they have increased resistance to various antimicrobial agents, which means infected implants often require multiple procedures and prolonged antibiotic therapy. […]
NON-CONTACT INDUCTION HEATING AND SAAP-148 ELIMINATE PERSISTERS WITHIN MRSA BIOFILMS MIMICKING A METAL IMPLANT INFECTION
Implant-associated infections are the primary cause of complications following orthopaedic surgery. Dueto biofilm and persister formation, current treatments, i.e. surgical debridement followed by antibiotics,often fail. There is an urgent need for alternative strategies to combat such infections. Therefore, the presentstudy investigated the effects of non-contact induction heating (NCIH), the antimicrobial peptide SAAP-148and combinations thereof on […]
Are infectious diseases and microbiology new fields for thermal therapy research?
Antimicrobial chemotherapy and surgery are classical methods for treating infectious diseases. However, there is a need for alternative methods to cure infections caused by antibiotic-resistant pathogens, recurrent or chronic infections, and unreachable local infections in which the use of drugs or surgery is anatomically and physically restricted. https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1440015
Non-contact electromagnetic induction heating for eradicating bacteria and yeasts on biomaterials and possible relevance to orthopaedic implant infections
Infection of implants is a major problem in elective and trauma surgery. Heating is an effective way to reduce the bacterial load in food preparation, and studies on hyperthermia treatment for cancer have shown that it is possible to heat metal objects with pulsed electromagnetic fields selectively (PEMF), also known as induction heating. We therefore […]
Segmental induction heating of orthopaedic metal implants
Prosthetic joint infection (PJI) is a devastating complication following total joint arthroplasty. Non-contact induction heating of metal implants is a new and emerging treatment for PJI. However, there may be concerns for potential tissue necrosis. It is thought that segmental induction heating can be used to control the thermal dose and to limit collateral thermal […]