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Millions of arthroplasties are performed worldwide each year. One of the biggest problems of a total joint replacement is a prosthetic joint infection (PJI), which is reported in 1-2% of cases. This adds up to more than 100.000 cases of PJI worldwide and more than 600.000 when Trauma plates, Oncology & Spine metal implants are included . Bacteria on the implant build a layer called the biofilm which can only be treated insufficiently with antibiotics and mechanically by wound irrigation. The consequences are repeated, costly and burdensome irrigation procedures, which may eventually lead to the total replacement of the prosthesis or metal implant.